CHOLESTEROL ESTER HYDROLYSIS AND HORMONE-SENSITIVE LIPASE IN LACTATING RAT MAMMARY TISSUE

被引：18
|
作者：
SMALL, CA
YEAMAN, SJ
WEST, DW
CLEGG, RA
机构：
[1] HANNAH RES INST,AYR KA6 5HL,SCOTLAND
[2] UNIV NEWCASTLE UPON TYNE,DEPT BIOCHEM & GENET,NEWCASTLE TYNE NE1 7RU,TYNE & WEAR,ENGLAND
来源：
BIOCHIMICA ET BIOPHYSICA ACTA | 1991年 / 1082卷 / 03期
关键词：
HORMONE-SENSITIVE LIPASE; CHOLESTEROL ESTER HYDROLASE; MAMMARY TISSUE; PROTEIN PHOSPHORYLATION;
D O I：
10.1016/0005-2760(91)90200-2
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Neutral cholesterol esterase activity is expressed in extracts of mammary epithelial cells. The identity of the enzyme catalyzing this hydrolysis was investigated. Anti-hormone-sensitive lipase immunoglobulin elicited the total inhibition of this activity and also immunoprecipitated a single phosphoprotein of M(r) 84 kDa from mammary cell extracts previously phosphorylated in vitro with [gamma-P-32]ATP and cyclic AMP-dependent protein kinase. It is concluded that mammary cell cholesterol esterase activity results from the presence of hormone-sensitive lipase.
引用
收藏
页码：251 / 254
页数：4
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