CHOLESTEROL ESTER HYDROLYSIS AND HORMONE-SENSITIVE LIPASE IN LACTATING RAT MAMMARY TISSUE

被引：18
|
作者：
SMALL, CA
YEAMAN, SJ
WEST, DW
CLEGG, RA
机构：
[1] HANNAH RES INST,AYR KA6 5HL,SCOTLAND
[2] UNIV NEWCASTLE UPON TYNE,DEPT BIOCHEM & GENET,NEWCASTLE TYNE NE1 7RU,TYNE & WEAR,ENGLAND
来源：
BIOCHIMICA ET BIOPHYSICA ACTA | 1991年 / 1082卷 / 03期
关键词：
HORMONE-SENSITIVE LIPASE; CHOLESTEROL ESTER HYDROLASE; MAMMARY TISSUE; PROTEIN PHOSPHORYLATION;
D O I：
10.1016/0005-2760(91)90200-2
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Neutral cholesterol esterase activity is expressed in extracts of mammary epithelial cells. The identity of the enzyme catalyzing this hydrolysis was investigated. Anti-hormone-sensitive lipase immunoglobulin elicited the total inhibition of this activity and also immunoprecipitated a single phosphoprotein of M(r) 84 kDa from mammary cell extracts previously phosphorylated in vitro with [gamma-P-32]ATP and cyclic AMP-dependent protein kinase. It is concluded that mammary cell cholesterol esterase activity results from the presence of hormone-sensitive lipase.
引用
收藏
页码：251 / 254
页数：4
相关论文
共 50 条
  • [21] Hormone-sensitive lipase: control of intracellular tri-(di-)acylglycerol and cholesteryl ester hydrolysis
    Kraemer, FB
    Shen, WJ
    JOURNAL OF LIPID RESEARCH, 2002, 43 (10) : 1585 - 1594
  • [22] ACTIVATION OF HORMONE-SENSITIVE LIPASE IN EXTRACTS OF ADIPOSE TISSUE
    TSAI, SC
    BELFRAGE, P
    VAUGHAN, M
    JOURNAL OF LIPID RESEARCH, 1970, 11 (05) : 466 - &
  • [23] Elimination of cholesterol ester accumulated in foam cells by adenovirus-mediated overexpression of hormone-sensitive lipase
    Okazaki, H
    Osuga, JI
    Tamura, Y
    Kitamine, T
    Tomita, S
    Iizuka, Y
    Yahagi, N
    Ohashi, K
    Tsukamoto, K
    Ishibashi, S
    CIRCULATION, 2001, 104 (17) : 45 - 45
  • [24] Expression, activity, and localization of hormone-sensitive lipase in rat mammary gland during pregnancy and lactation
    Martín-Hidalgo, A
    Huerta, L
    Alvarez, N
    Alegría, G
    del Val Toledo, M
    Herrera, E
    JOURNAL OF LIPID RESEARCH, 2005, 46 (04) : 658 - 668
  • [25] Hormone-sensitive lipase activity and triacylglycerol hydrolysis are decreased in rat soleus muscle by cyclopiazonic acid
    Watt, MJ
    Steinberg, GR
    Heigenhauser, GJF
    Spriet, LL
    Dyck, DJ
    AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2003, 285 (02): : E412 - E419
  • [26] Hormone-sensitive lipase is a retinyl ester hydrolase in human and rat quiescent hepatic stellate cells
    Shajari, Shiva
    Saeed, Ali
    Smith-Cortinez, Natalia F.
    Heegsma, Janette
    Sydor, Svenja
    Faber, Klaas Nico
    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 2019, 1864 (09): : 1258 - 1267
  • [27] EFFECT ON CHOLESTERYL ESTER ACCUMULATION BY OVEREXPRESSION OF HORMONE-SENSITIVE LIPASE (HSL)
    LIU, GQ
    ABDULLAH, E
    DAVIS, RC
    SCHOTZ, MC
    CIRCULATION, 1993, 88 (04) : 178 - 178
  • [28] Regulation of hormone-sensitive lipase
    Shen, WJ
    Hong, R
    Liang, Y
    Patel, S
    Natu, V
    Bernhlor, D
    Kraemer, FB
    FASEB JOURNAL, 2001, 15 (04): : A19 - A19
  • [29] HYDROLYSIS OF CHOLESTEROL ESTERS IN PLASMA-LIPOPROTEINS BY HORMONE-SENSITIVE CHOLESTEROL ESTERASE FROM ADIPOSE-TISSUE
    KHOO, JC
    DREVON, CA
    STEINBERG, D
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1979, 254 (06) : 1785 - 1787
  • [30] Hormone-sensitive lipase knockouts
    Kraemer, Fredric B.
    Shen, Wen-Jun
    NUTRITION & METABOLISM, 2006, 3 (1)
12345