THE PAPILLOMAVIRUS E2 PROTEIN - A FACTOR WITH MANY TALENTS

被引：90

作者：

HAM, J

DOSTATNI, N

GAUTHIER, JM

YANIV, M

机构：

[1] Unité des Virus Oncogènes, Département des Biotechnologies, Centre National de la Recherche Scientifique, 75724 Paris, UA1149 du

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1991年 / 16卷 / 11期

关键词：

D O I：

10.1016/0968-0004(91)90172-R

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The products of the papillomavirus E2 open reading frame play a key role in the regulation of the viral cycle. E2 proteins can activate or repress viral promoters by several distinct mechanisms and viral DNA replication requires the expression of the full-length E2 protein together with the product of the E1 open reading frame. This is an interesting example of how a single eukaryotic DNA-binding protein has evolved to perform several different functions and it provides a valuable model system for studying the regulation of eukaryotic transcription and DNA replication.

引用

页码：440 / 444

页数：5

共 38 条

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