EVALUATION OF IFENPRODIL EFFICACY ON EXERCISE-INDUCED TISSUE ISCHEMIA IN STAGE-II ARTERIOPATHY BY MEASUREMENT OF TRANSCUTANEOUS OXYGEN-TENSION DURING A STANDARD TREADMILL TEST - DOUBLE-BLIND-STUDY OF INJECTABLE IFENPRODIL VERSUS PLACEBO

被引：3

作者：

CAILLARD, P ^{[1
]}

MOUREN, X ^{[1
]}

BAILLIART, O ^{[1
]}

CLOAREC, M ^{[1
]}

机构：

[1] HOP LARIBOISIERE,SERV EXPLOR FONCT,F-75475 PARIS 10,FRANCE

来源：

ANGIOLOGY | 1993年 / 44卷 / 07期

关键词：

D O I：

10.1177/000331979304400707

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Measurement of transcutaneous oxygen tension (TcPO2) is a noninvasive and easily reproducible method for objectifying and quantifying exercise ischemia in patients with stage II occlusive arterial disease. This technique is also used at rest to evaluate the therapeutic effect of vasoactive treatments. To objectively assess the effectiveness of a vasoactive treatment on the conditions of tissue perfusion, a randomized double-blind study of ifenprodil tartrate versus placebo was performed in 20 patients, whose TcPO2 was continuously measured while they walked on a treadmill. Patients treated with ifenprodil improved significantly as compared with the placebo group, for both the half-hypoxia area, representing the overall evolution of the tissue ischemia (+34.9% and -16.0%, respectively, p = 0.01), and the half-hypoxia recovery time, estimating the postexercise recovery time (+30.2% and -3.6%, respectively, p < 0.05). This study confirms that the continuous measurement of TcPO2 during the recovery phase after exercise represents an objective method for the evaluation and follow-up of patients with stage II intermittent claudication. The results enabled the objective assessment of ifenprodil efficacy on the evolution of tissue hypoxia.

引用

页码：552 / 560

页数：9

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