CHIRAL SEPARATION OF BASIC DRUGS USING CYCLODEXTRINS AS CHIRAL PSEUDO-STATIONARY PHASES IN CAPILLARY ELECTROPHORESIS

被引：123

作者：

HEUERMANN, M ^{[1
]}

BLASCHKE, G ^{[1
]}

机构：

[1] UNIV MUNSTER,DEPT PHARMACEUT CHEM,HITTORFSTR 58-62,D-48149 MUNSTER,GERMANY

来源：

JOURNAL OF CHROMATOGRAPHY | 1993年 / 648卷 / 01期

关键词：

D O I：

10.1016/0021-9673(93)83310-O

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Capillary electrophoresis was used for the chiral resolution of basic racemic drugs in general and in particular for dimethindene and four possible metabolites. Conditions for optimum enantioselectivity and resolution were determined by changing the cyclodextrin type, cyclodextrin concentration, pH of the run buffer, applied current and capillary temperature.

引用

页码：267 / 274

页数：8

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