ANTICARDIOLIPIN ANTIBODIES IN A SAMPLE OF CHRONIC-SCHIZOPHRENICS RECEIVING NEUROLEPTIC THERAPY

被引：26

作者：

METZER, WS

CANOSO, RT

NEWTON, JEO

机构：

[1] MCCLELLAN MEM VET ADM MED CTR,NEUROL SERV,LITTLE ROCK,AR

[2] MCCLELLAN MEM VET ADM MED CTR,PSYCHIAT SERV,LITTLE ROCK,AR

[3] UNIV ARKANSAS MED SCI HOSP,DEPT NEUROL,LITTLE ROCK,AR

[4] UNIV ARKANSAS MED SCI HOSP,DEPT PSYCHIAT,LITTLE ROCK,AR

[5] HARVARD UNIV,SCH MED,DEPT INTERNAL MED,CAMBRIDGE,MA

[6] BROCKTON W ROXBURY VET ADM MED CTR,HEMATOL ONCOL SECT,BROCKTON,MA

来源：

SOUTHERN MEDICAL JOURNAL | 1994年 / 87卷 / 02期

关键词：

D O I：

10.1097/00007611-199402000-00008

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Drug-induced antiphospholipid antibodies have been considered insignificant, a belief that has recently been questioned. Previous studies noted an association between chlorpromazine treatment and the presence of anticardiolipin antibodies (ACA), especially IgM ACA, and have suggested that thrombosis might ht be more likely in the presence of IgG ACA. We studied the cases of 27 patients receiving long-term neuroleptic therapy who had no history of cerebrovascular disease. IgG ACA was present in 7 (26%) of the 27, and IgM ACA was present in 5 (19%), yet none had shown any manifestations of cerebrovascular disease since initiation of neuroleptic therapy. These data suggest that drug-induced ACA do not predispose to cerebrovascular disease, even when IgG ACA is predominant.

引用

页码：190 / 192

页数：3

共 20 条

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