FTO rs9939609 Does Not Interact with Physical Exercise but Influences Basal Insulin Metabolism in Brazilian Overweight and Obese Adolescents

被引：16

作者：

do Nascimento, Gabrielle Araujo ^{[1
]}

Leite, Neiva ^{[2
]}

Furtado-Alle, Lupe ^{[1
]}

Teixeira, Mayza Dalcin ^{[1
]}

Rodrigues de Souza, Ricardo Lehtonen ^{[1
]}

Milano, Gerusa Eisfeld ^{[2
]}

da Silva, Larissa Rosa ^{[2
]}

Pizzi, Juliana ^{[2
]}

Lopes, Wendell Arthur ^{[3
]}

Aguiar Lopes, Maria de Fatima ^{[2
]}

Kapp Titski, Ana Claudia ^{[2
]}

Tureck, Luciane Viater ^{[1
,4
]}

机构：

[1] Univ Fed Parana, Setor Ciencias Biol, Ctr Politecn, Dept Genet, 210 Jardim Amer, BR-81531970 Curitiba, Parana, Brazil

[2] Univ Fed Parana, Dept Phys Educ, 92 Jardim Bot, BR-80215370 Curitiba, Parana, Brazil

[3] Univ Estadual Maringa, Dept Phys Educ, Ave Colombo 5790, BR-87020900 Maringa, Parana, Brazil

[4] Univ Tecnol Fed Parana, Acad Dept Educ, Ave Monteiro Lobato Km 04, BR-84016210 Ponta Grossa, PR, Brazil

来源：

JOURNAL OF OBESITY | 2018年 / 2018卷

关键词：

D O I：

10.1155/2018/3134026

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Purpose. The rs9939609 SNP (T > A) in FTO gene is associated with obesity and type 2 diabetes. The present study aimed at verifying whether this SNP influenced biochemical outcomes of children and adolescents who are overweight/obese submitted to a program of physical exercise and also if there was influence on basal levels of these biochemical variables. Methods. The sample was composed by 432 children and adolescents grouped in three ways (obese, overweight, and normal weight); of these, 135 children and adoloescents who are obese and overweight were submitted to a physical exercise program for 12 weeks. All were genotyped by TaqMan SNP genotyping assay. Results. The children and adolescents who are overweight/obese and carriers of AA genotype had higher levels of insulin (p = 0.03) and HOMA (p = 0.007) and lower levels of glucose (p = 0.003), but the SNP did not modulate the response to physical exercise. Conclusions. In our study, the rs9939609 AA genotype was associated with parameters related to insulin metabolism but did not interact with physical exercise.

引用

页数：8

共 49 条

[1] Association of the rs9939609 gene variant in FTO with insulin resistance, cardiovascular risk factor and serum adipokine levels in obese patients [J].