NOVEL ANTIMYCIN ANTIBIOTICS, URAUCHIMYCIN-A AND URAUCHIMYCIN-B, PRODUCED BY MARINE ACTINOMYCETE

被引:64
作者
IMAMURA, N
NISHIJIMA, M
ADACHI, K
SANO, H
机构
[1] Shimizu Institute, Marine Biotechnology Institute Co., Ltd, Shimizu, 424, Meguro-ku
关键词
D O I
10.7164/antibiotics.46.241
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Two novel antimycin antibiotics, urauchimycins A and B, were isolated from a fermentation broth of a Streptomyces sp. Ni-80. The strain was isolated from an unidentified sponge. Their chemical structures were determined by 2D NMR analysis. They are the first antimycin antibiotics which possess a branched side chain moiety. They exhibited inhibitory activity against morphological differentiation of Candida albicans.
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页码:241 / 246
页数:6
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