BETA-AMYLOID PEPTIDES INDUCE DEGENERATION OF CULTURED RAT MICROGLIA

被引：78

作者：

KOROTZER, AR ^{[1
]}

PIKE, CJ ^{[1
]}

COTMAN, CW ^{[1
]}

机构：

[1] UNIV CALIF IRVINE,DEPT PSYCHOBIOL,IRVINE,CA 92717

来源：

BRAIN RESEARCH | 1993年 / 624卷 / 1-2期

关键词：

ALZHEIMER; BETA-AMYLOID; AGGREGATION; RAMIFIED MICROGLIA; SENILE PLAQUE;

D O I：

10.1016/0006-8993(93)90068-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Microglia are often associated with senile plaques, a primary pathological hallmark of Alzheimer's disease (AD) that consists largely of insoluble deposits of beta-amyloid (Abeta) protein. Synthetic Abeta peptides have been shown to induce neurite dystrophy and neuronal death in vitro when the peptides are assembled into aggregates. We now report that assembled Abeta peptides induce morphological evidence of degeneration in process-bearing microglia in vitro, as well as metabolic dysfunction in microglial cultures, but a non-assembling scrambled sequence Abeta peptide does not.

引用

页码：121 / 125

页数：5

共 23 条

[1] BETA-AMYLOID STIMULATES GLIAL-CELLS INVITRO TO PRODUCE GROWTH-FACTORS THAT ACCUMULATE IN SENILE PLAQUES IN ALZHEIMERS-DISEASE [J].