TIME-DEPENDENT RESPONSE OF IONIC POLYMER NETWORKS TO PH AND IONIC-STRENGTH CHANGES

被引：39

作者：

BRANNONPEPPAS, L ^{[1
]}

PEPPAS, NA ^{[1
]}

机构：

[1] PURDUE UNIV,SCH CHEM ENGN,W LAFAYETTE,IN 47907

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1991年 / 70卷 / 1-2期

关键词：

ANIONIC HYDROGEL; NETWORK; PH CHANGE; SWELLING; BOLTZMANN SUPERPOSITION;

D O I：

10.1016/0378-5173(91)90163-I

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Changes of ionic strength of pH of a swelling medium may lead to expansion or contraction of ionic polymer networks or charged hydrogels which have been immersed in this swelling medium. This phenomenon is analyzed by using a Boltzmann superposition equation which relates the strain to the applied ionic strength or pH. A material property, the ionic mechanochemical compliance, L(t - tau), is introduced which describes the viscoelastic response of a gel to the swelling environment. Experiment results of swelling of anionically charged hydrogels are presented and analyzed.

引用

页码：53 / 57

页数：5

共 13 条

[1]

AKLONIS JJ, 1983, INTRO POLYM VISCOELA

[2]

Brannon-Peppas L.R., 1990, ABSORBENT POLYM TECH

[3] SOLUTE AND PENETRANT DIFFUSION IN SWELLABLE POLYMERS .9. THE MECHANISMS OF DRUG RELEASE FROM PH-SENSITIVE SWELLING-CONTROLLED SYSTEMS [J].