EFFECT OF GENETIC BACKGROUND ON COSEGREGATION OF RENIN ALLELES AND BLOOD-PRESSURE IN DAHL RATS

被引：56
作者：
RAPP, JP
WANG, SM
DENE, H
机构：
[1] The Department of Medicine and Department of Pathology, Medical College of Ohio
来源：
AMERICAN JOURNAL OF HYPERTENSION | 1990年 / 3卷 / 05期
关键词：
Dahl rats; Genetics; Renin gene; Salt induced hypertension; Salt sensitive rats;
D O I：
10.1093/ajh/3.5.391
中图分类号：
R6 [外科学];
学科分类号：
1002 ; 100210 ;
摘要：
The cosegregation of renin alleles and blood pressure was evaluated in segregating populations derived from inbred Dahl salt hypertension sensitive (S) and inbred Dahl salt hypertension resistant (R) rats. The populations were raised on high salt diet (8% NaCl). In F2and F1X S populations, there was a significant positive gene-dosage relationship between the S-rat renin allele and blood pressure. In contrast, no such relationship was seen in the F1X R population. Since in the F1X R population the genetic background is strongly influenced by genes from the R rat (75% R, 25% S), the result is interpreted to mean that genes at other (unidentified) loci modify the blood pressure effect of the S-rat renin allele. © 1990 by the American Journal of Hypertension, Ltd.
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收藏
页码：391 / 396
页数：6
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