Synthesis of 2-alkylamino-4-methylquinoline-6-R'-phenylsulfamides and their antimicrobial activity

被引：0

作者：

Oleksiyenko, T. O. ^{[1
]}

Gritsenko, I. S. ^{[1
]}

Osolodchenko, T. P. ^{[2
]}

机构：

[1] Natl Pharmaceutical Univ, Kharkov, Ukraine

[2] Inst Microbiol & Immunol, Lab Biochem Microorganisms & Nutr, Kharkov, Ukraine

来源：

ZAPOROZHYE MEDICAL JOURNAL | 2013年 / 02期

关键词：

quinoline; aminoquinoline; sulfamide; synthesis; antimicrobial activity;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Series of new 2-alkylamino-4-methylquinoline-6-phenylsulfamides was obtained by the reaction of 2-chloro-4-methylquinoline-6phenylsulfamides with appropriate aliphatic amines in conditions of microwave radiation and their physical and chemical characteristics were studied. The results of microbiological screening revealed that the synthesized compounds showed high activity against Gram-positive microorganisms and C. albicans, but revealed less active effect against gram-negative microorganisms. Some "structure-activity" relationships have been found.

引用

页码：94 / 97

页数：4

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