Synthesis of 2-alkylamino-4-methylquinoline-6-R'-phenylsulfamides and their antimicrobial activity

被引：0
|
作者：
Oleksiyenko, T. O. [1 ]
Gritsenko, I. S. [1 ]
Osolodchenko, T. P. [2 ]
机构：
[1] Natl Pharmaceutical Univ, Kharkov, Ukraine
[2] Inst Microbiol & Immunol, Lab Biochem Microorganisms & Nutr, Kharkov, Ukraine
来源：
ZAPOROZHYE MEDICAL JOURNAL | 2013年 / 02期
关键词：
quinoline; aminoquinoline; sulfamide; synthesis; antimicrobial activity;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Series of new 2-alkylamino-4-methylquinoline-6-phenylsulfamides was obtained by the reaction of 2-chloro-4-methylquinoline-6phenylsulfamides with appropriate aliphatic amines in conditions of microwave radiation and their physical and chemical characteristics were studied. The results of microbiological screening revealed that the synthesized compounds showed high activity against Gram-positive microorganisms and C. albicans, but revealed less active effect against gram-negative microorganisms. Some "structure-activity" relationships have been found.
引用
收藏
页码：94 / 97
页数：4
相关论文
共 50 条
  • [1] Synthesis and antimicrobial activity of 2-chloro-6-methylquinoline hydrazone derivatives
    Bawa, Sandhya
    Kumar, Suresh
    Drabu, Sushma
    Kumar, Rajiv
    JOURNAL OF PHARMACY AND BIOALLIED SCIENCES, 2009, 1 (01): : 27 - 31
  • [2] Synthesis and evaluation of the trypanocydal activity of 4-alkylamino-6-nitroquinolines
    Tapia, RA
    Prieto, Y
    Zamora, G
    Morello, A
    Repetto, Y
    HETEROCYCLIC COMMUNICATIONS, 2000, 6 (06) : 539 - 544
  • [3] Synthesis and Antimicrobial Evaluation of 6-Alkylamino-N-phenylpyrazine-2-carboxamides
    Servusova-Vanaskova, Barbora
    Paterova, Pavla
    Garaj, Vladimir
    Mandikova, Jana
    Kunes, Jiri
    Naesens, Lieve
    Jilek, Petr
    Dolezal, Martin
    Zitko, Jan
    CHEMICAL BIOLOGY & DRUG DESIGN, 2015, 86 (04) : 674 - 681
  • [4] Synthesis and In-vitro Antimicrobial Activity of Secondary and Tertiary Amines Containing 2-Chloro-6-methylquinoline Moiety
    Kumar, Suresh
    Bawa, Sandhya
    Kaushik, Darpan
    Panda, Bibhu P.
    ARCHIV DER PHARMAZIE, 2011, 344 (07) : 474 - 480
  • [5] Synthesis and Transformations of 4-Hydroxy-2-methylquinoline-6-carbohydrazide
    Aleksanyan, I. L.
    Hambardzumyan, L. P.
    RUSSIAN JOURNAL OF ORGANIC CHEMISTRY, 2019, 55 (02) : 262 - 265
  • [6] Synthesis and Transformations of 4-Hydroxy-2-methylquinoline-6-carbohydrazide
    I. L. Aleksanyan
    L. P. Hambardzumyan
    Russian Journal of Organic Chemistry, 2019, 55 : 262 - 265
  • [7] SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF PRODUCTS SUBSEQUENT TO CONDENSATION OF ALLOXAN WITH 2-METHYLQUINOLINE DERIVATIVES
    PRISYAZHNYUK, PV
    PALIY, GK
    VOLYANSKY, YL
    OPANASENKO, EP
    LOPUSHANSKY, AI
    KHIMIKO-FARMATSEVTICHESKII ZHURNAL, 1977, 11 (03): : 37 - 41
  • [8] THERMOCHEMICAL STUDY OF 2-METHYLQUINOLINE, 4-METHYLQUINOLINE, 6-METHYLQUINOLINE, AND 8-METHYLQUINOLINE
    DASILVA, MAVR
    MATOS, MAR
    AMARAL, LMPF
    JOURNAL OF CHEMICAL THERMODYNAMICS, 1995, 27 (06): : 565 - 574
  • [9] Design and synthesis of new N′-substituted-2-methylquinoline-3-carbohydrazides with antioxidant and antimicrobial activity
    Maddela, Srinubabu
    Venugopal, Muralidharan
    Maddela, Rambabu
    Ajitha, Makula
    INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 2015, 54 (07): : 930 - 935
  • [10] 4-Azido-2-chloro-6-methylquinoline
    Natarajan, S.
    Rajesh, K.
    Vijayakumar, V.
    Suresh, J.
    Lakshman, P. L. Nilantha
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2009, 65 : O671 - U1284
12345