GLUTAMATE PARTICIPATES IN THE PERIPHERAL MODULATION OF THERMAL HYPERALGESIA IN RATS

被引：162

作者：

JACKSON, DL ^{[1
]}

GRAFF, CB ^{[1
]}

RICHARDSON, JD ^{[1
]}

HARGREAVES, KM ^{[1
]}

机构：

[1] UNIV MINNESOTA,SCH DENT,DEPT PHARMACOL,MINNEAPOLIS,MN 55455

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1995年 / 284卷 / 03期

关键词：

GLUTAMATE; MK-801; CNQX (6-CYANO-7-NITROQUINOXALINE-2,3-DIONE); INFLAMMATION; PAIN; ANALGESIA;

D O I：

10.1016/0014-2999(95)00449-U

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

While the effects of excitatory amino acids have been well characterized in the central nervous system, relatively little is known about their possible modulation of elements responsible for hyperalgesia within peripheral tissue. The presented experiments demonstrate that the intraplantar (i.pl.) injection of L-glutamate (30 nmol) evokes a thermal hyperalgesic response in the paw withdrawal latencies of normal rats which is stereospecific. In addition, the i.pl. injection of either the non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist MK-801 (10 nmol) or the competitive alpha-amino-3-hydroxy-4-methyl-5-isoxazolepropionic acid (AMPA)/kainate receptor antagonist 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) (100 nmol) into hind paws inflamed with carrageenan significantly reduced the thermal hyperalgesic response in rats. Collectively, these results suggest that excitatory amino acids activate a peripheral target which facilitates a hyperalgesic behavioral response to thermal stimulation via a receptor mediated process.

引用

页码：321 / 325

页数：5

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