CYCLOSPORINE-TREATED RENAL-TRANSPLANT PATIENTS HAVE ONLY PARTIAL INHIBITION OF CALCINEURIN PHOSPHATASE-ACTIVITY

被引：0

作者：

BATIUK, TD ^{[1
]}

PAZDERKA, F ^{[1
]}

HALLORAN, PF ^{[1
]}

机构：

[1] UNIV ALBERTA,DEPT MED,DIV NEPHROL & IMMUNOL,EDMONTON,AB T6G 2R8,CANADA

来源：

TRANSPLANTATION PROCEEDINGS | 1995年 / 27卷 / 01期

关键词：

D O I：

暂无

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

引用

页码：840 / 841

页数：2

共 9 条

[1]

BATIUK TD, 1994, TRANSPLANT P, V26, P2831

[2] IDENTIFICATION OF CALCINEURIN AS A KEY SIGNALING ENZYME IN LYMPHOCYTE-T ACTIVATION [J].

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[3] CALCINEURIN PHOSPHATASE-ACTIVITY IN LYMPHOCYTES-T IS INHIBITED BY FK-506 AND CYCLOSPORINE-A [J].

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (09) :3686-3690

[4] CALCINEURIN IS A COMMON TARGET OF CYCLOPHILIN-CYCLOSPORINE-A AND FKBP-FK506 COMPLEXES [J].

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[5] INHIBITION OF T-CELL SIGNALING BY IMMUNOPHILIN LIGAND COMPLEXES CORRELATES WITH LOSS OF CALCINEURIN PHOSPHATASE-ACTIVITY [J].

LIU, J ;

ALBERS, MW ;

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KLEE, CB ;

SCHREIBER, SL .

BIOCHEMISTRY, 1992, 31 (16) :3896-3901

[6] FK-506-SENSITIVE AND CSA-SENSITIVE ACTIVATION OF THE INTERLEUKIN-2 PROMOTER BY CALCINEURIN [J].

OKEEFE, SJ ;

TAMURA, J ;

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TOCCI, MJ ;

ONEILL, EA .

NATURE, 1992, 357 (6380) :692-694

[7]

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[8] THE MECHANISM OF ACTION OF CYCLOSPORINE-A AND FK506 [J].

SCHREIBER, SL ;

CRABTREE, GR .

IMMUNOLOGY TODAY, 1992, 13 (04) :136-142

[9]

TRENN G, 1989, J IMMUNOL, V142, P3796

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