BRAIN-DERIVED NEUROTROPHIC FACTOR EXPRESSION AFTER LONG-TERM POTENTIATION

被引：137
作者：
DRAGUNOW, M
BEILHARZ, E
MASON, B
LAWLOR, P
ABRAHAM, W
GLUCKMAN, P
机构：
[1] UNIV AUCKLAND,SCH MED,DEPT PEDIAT,AUCKLAND,NEW ZEALAND
[2] UNIV OTAGO,DEPT PSYCHOL,DUNEDIN,NEW ZEALAND
来源：
NEUROSCIENCE LETTERS | 1993年 / 160卷 / 02期
关键词：
LTP; GROWTH FACTOR; MEMORY; HIPPOCAMPUS; BDNF; RETROGRADE MESSENGER;
D O I：
10.1016/0304-3940(93)90420-P
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Long-term potentiation (LTP) of perforant-path dentate granule cell synapses, in awake rats, was followed by a time-dependent expression of brain-derived neurotrophic factor (BDNF) mRNA in dentate granule cells. This BDNF expression was blocked by the N-methyl-D-aspartate (NMDA) antagonist dizocilpine maleate (MK-801), which also blocked LTP induction, and by sodium pentobarbital, which shortens LTP persistence. These results suggest that BDNF may participate in the NMDA-receptor mediated cascade of events that result in LTP stabilization.
引用
收藏
页码：232 / 236
页数：5
相关论文
共 25 条
[1]   THE ROLE OF IMMEDIATE EARLY GENES IN THE STABILIZATION OF LONG-TERM POTENTIATION [J].
ABRAHAM, WC ;
DRAGUNOW, M ;
TATE, WP .
MOLECULAR NEUROBIOLOGY, 1991, 5 (2-4) :297-314
[2]   EFFECTS OF THE NMDA RECEPTOR CHANNEL ANTAGONISTS CPP AND MK801 ON HIPPOCAMPAL FIELD POTENTIALS AND LONG-TERM POTENTIATION IN ANESTHETIZED RATS [J].
ABRAHAM, WC ;
MASON, SE .
BRAIN RESEARCH, 1988, 462 (01) :40-46
[3]   HIPPOCAMPAL DAMAGE AND KAINIC ACID INJECTION INDUCE A RAPID INCREASE IN MESSENGER-RNA FOR BDNF AND NGF IN THE RAT-BRAIN [J].
BALLARIN, M ;
ERNFORS, P ;
LINDEFORS, N ;
PERSSON, H .
EXPERIMENTAL NEUROLOGY, 1991, 114 (01) :35-43
[4]   LONG-LASTING POTENTIATION OF SYNAPTIC TRANSMISSION IN DENTATE AREA OF ANESTHETIZED RABBIT FOLLOWING STIMULATION OF PERFORANT PATH [J].
BLISS, TVP ;
LOMO, T .
JOURNAL OF PHYSIOLOGY-LONDON, 1973, 232 (02) :331-356
[5]   A SYNAPTIC MODEL OF MEMORY - LONG-TERM POTENTIATION IN THE HIPPOCAMPUS [J].
BLISS, TVP ;
COLLINGRIDGE, GL .
NATURE, 1993, 361 (6407) :31-39
[6]   PHOTOCHEMICAL STROKE AND BRAIN-DERIVED NEUROTROPHIC FACTOR (BDNF) MESSENGER-RNA EXPRESSION [J].
COMELLI, MC ;
SEREN, MS ;
GUIDOLIN, D ;
MANEV, RM ;
FAVARON, M ;
RIMLAND, JM ;
CANELLA, R ;
NEGRO, A ;
MANEV, H .
NEUROREPORT, 1992, 3 (06) :473-476
[7]  
DEMELLO SR, 1992, J NEUROSCI RES, V33, P419
[8]   DIFFERENTIAL EXPRESSION OF IMMEDIATE EARLY GENES AFTER HIPPOCAMPAL LONG-TERM POTENTIATION IN AWAKE RATS [J].
DEMMER, J ;
DRAGUNOW, M ;
LAWLOR, PA ;
MASON, SE ;
LEAH, JD ;
ABRAHAM, WC ;
TATE, WP .
MOLECULAR BRAIN RESEARCH, 1993, 17 (3-4) :279-286
[9]   HIGH-FREQUENCY DISCHARGE OF DENTATE GRANULE CELLS, BUT NOT LONG-TERM POTENTIATION, INDUCES C-FOS PROTEIN [J].
DOUGLAS, RM ;
DRAGUNOW, M ;
ROBERTSON, HA .
MOLECULAR BRAIN RESEARCH, 1988, 4 (03) :259-262
[10]   LONG-TERM POTENTIATION AND THE INDUCTION OF C-FOS MESSENGER-RNA AND PROTEINS IN THE DENTATE GYRUS OF UNANESTHETIZED RATS [J].
DRAGUNOW, M ;
ABRAHAM, WC ;
GOULDING, M ;
MASON, SE ;
ROBERTSON, HA ;
FAULL, RLM .
NEUROSCIENCE LETTERS, 1989, 101 (03) :274-280
123