MECHANISM OF BICARBONATE SECRETION IN RAT (RATTUS-RATTUS) COLON

被引：9

作者：

DAGHER, PC ^{[1
]}

RHO, JI ^{[1
]}

CHARNEY, AN ^{[1
]}

机构：

[1] NYU, SCH MED, DEPT VET AFFAIRS MED CTR, NEPHROL SECT, NEW YORK, NY 10010 USA

来源：

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY | 1993年 / 105卷 / 01期

关键词：

D O I：

10.1016/0300-9629(93)90171-Y

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

1. Colonic HCO3 secretion was measured as the residual flux in male Sprague Dawley rats (Rattus rattus). 2. Basal HCO3 secretion was increased by 1 mM dibutyryl cyclic AMP (dbcAMP) and was reduced to baseline by 0.1 mM methazolamide (Mtz) but not by SITS (1 mM), DIDS (1 mM) or amiloride (1 mM). 3. In vivo, intravenous vasoactive intestinal peptide increased HCO3 secretion and prior perfusion with 1 mM Mtz prevented this increase. 4. These results suggest that the source of basal and cAMP-stimulated HCO3 secretion is, in part, intracellular and requires the action of carbonic anhydrase.

引用

页码：43 / 48

页数：6

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