PROPERTIES AND FUNCTION OF LYSYL OXIDASE

被引：302
作者：
KAGAN, HM
TRACKMAN, PC
机构：
[1] Department of Biochemistry, Boston University School of Medicine, Massachusetts
来源：
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY | 1991年 / 5卷 / 03期
关键词：
D O I：
10.1165/ajrcmb/5.3.206
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Lysyl oxidase catalyzes the oxidation of peptidyl lysine to alpha-aminoadipic-delta-semialdehyde, the precursor to the covalent crosslinkages that stabilize fibers of elastin and collagen. This enzyme contains both copper and a carbonyl cofactor consistent with an o-quinone. The proposed mechanism of action is derived from available kinetic and chemical data and also can account for mechanism-based inhibition of the enzyme by specific monoamines and diamines. Recent evidence for biosynthetic precursors and for the regulation of lysyl oxidase in fibrotic and malignant diseases is discussed.
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页码：206 / 210
页数：5
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