DIASTEREOMERIC SEPARATION OF ALPHA-AMINO-ACID DERIVATIVES USING A CHIRAL CARBODIIMIDE

被引：6

作者：

KASIMURA, H

KISHIKAWA, K

KOHMOTO, S

YAMAMOTO, M

YAMADA, K

机构：

[1] Department of Industrial Chemistry, Faculty of Engineering, Chiba University, Chiba-shi, Chiba, 260

来源：

ANALYTICA CHIMICA ACTA | 1990年 / 239卷 / 02期

关键词：

Amino acids; Carbodiimides; Chiral derivatization; Ivory identification;

D O I：

10.1016/S0003-2670(00)83865-9

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

N,N′-Bis[(S)-1-phenylethyl]carbodiimide (1) was found to be an efficient chiral derivatizing agent for the diastereomeric separation of 2-N-benzyloxycarbonylamino acids (2). Diastereomeric acylureas prepared from 1 and 2 showed a large chromatographic selectivity (α). Their capacity factors and selectivity depend on the carbon chain length of the α-alkyl substituents of acylureas. © 1990.

引用

页码：297 / 299

页数：3

共 7 条

[1]

BODANSZKY M, 1984, PRACTICE PEPTIDE SYN, P12

[2] DIRECTED RESOLUTION OF ENANTIOMERS VIA LIQUID-CHROMATOGRAPHY OF DIASTEREOMERIC DERIVATIVES .4. EXTREME LIQUID-CHROMATOGRAPHIC SEPARATION EFFECTS IN THE CASE OF DIASTEREOMERIC AMIDES CONTAINING POLAR SUBSTITUENTS [J].