CATECHOL-O-METHYLTRANSFERASE-INHIBITING PYROCATECHOL DERIVATIVES - SYNTHESIS AND STRUCTURE-ACTIVITY STUDIES

被引：104

作者：

BORGULYA, J ^{[1
]}

BRUDERER, H ^{[1
]}

BERNAUER, K ^{[1
]}

ZURCHER, G ^{[1
]}

DAPRADA, M ^{[1
]}

机构：

[1] F HOFFMANN LA ROCHE & CO LTD,DEPT PHARMACEUT RES,CH-4002 BASEL,SWITZERLAND

来源：

HELVETICA CHIMICA ACTA | 1989年 / 72卷 / 05期

关键词：

D O I：

10.1002/hlca.19890720511

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

引用

页码：952 / 968

页数：17

共 38 条

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[3]

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[4]

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[5]

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[6] CATECHOL O-METHYLTRANSFERASE .10. 5-SUBSTITUTED 3-HYDROXY-4-METHOXYBENZOIC ACIDS (ISOVANILLIC ACIDS) AND 5-SUBSTITUTED 3-HYDROXY-4-METHOXYBENZALDEHYDES (ISOVANILLINS) AS POTENTIAL INHIBITORS [J].

BORCHARDT, RT ;

HUBER, JA ;

HOUSTON, M .

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[7]

CALNE DB, 1973, CLIN PHARMACOL THER, V14, P386

[8]

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[9]

COLZI A, 1989, EARLY DIAGNOSIS PREV, P191

[10]

DAPRADA M, 1984, EXPERIENTIA, V40, P1165

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