Concepts and challenges in cancer risk prediction for the space radiation environment

被引：69

作者：

Barcellos-Hoff, Mary Helen ^{[1
]}

Blakely, Eleanor A. ^{[2
]}

Burma, Sandeep ^{[3
]}

Fornace, Albert J., Jr. ^{[4
]}

Gerson, Stanton ^{[5
]}

Hlatky, Lynn ^{[6
]}

Kirsch, David G. ^{[7
]}

Luderer, Ulrike ^{[8
]}

Shay, Jerry ^{[3
]}

Wang, Ya ^{[9
]}

Weil, Michael M. ^{[10
]}

机构：

[1] NYU, Sch Med, New York, NY 10016 USA

[2] Lawrence Berkeley Natl Lab, Berkeley, CA USA

[3] Univ Texas Southwestern Med Ctr Dallas, Dallas, TX 75390 USA

[4] Georgetown Univ, Washington, DC USA

[5] Case Western Reserve Univ, Cincinnati, OH USA

[6] Tufts Univ, Ctr Canc Syst Biol, Boston, MA 02111 USA

[7] Duke Univ, Durham, NC USA

[8] Univ Calif Irvine, Irvine, CA USA

[9] Emory Univ, Atlanta, GA 30322 USA

[10] Colorado State Univ, Ft Collins, CO 80523 USA

来源：

LIFE SCIENCES IN SPACE RESEARCH | 2015年 / 6卷

关键词：

Galactic cosmic radiation; Cancer; Risk modeling; Radiation quality; Mouse models;

D O I：

10.1016/j.lssr.2015.07.006

中图分类号：

P1 [天文学];

学科分类号：

0704 ;

摘要：

Cancer is an important long-term risk for astronauts exposed to protons and high-energy charged particles during travel and residence on asteroids, the moon, and other planets. NASA's Biomedical Critical Path Roadmap defines the carcinogenic risks of radiation exposure as one of four type I risks. A type I risk represents a demonstrated, serious problem with no countermeasure concepts, and may be a potential "show-stopper" for long duration spaceflight. Estimating the carcinogenic risks for humans who will be exposed to heavy ions during deep space exploration has very large uncertainties at present. There are no human data that address risk from extended exposure to complex radiation fields. The overarching goal in this area to improve risk modeling is to provide biological insight and mechanistic analysis of radiation quality effects on carcinogenesis. Understanding mechanisms will provide routes to modeling and predicting risk and designing countermeasures. This white paper reviews broad issues related to experimental models and concepts in space radiation carcinogenesis as well as the current state of the field to place into context recent findings and concepts derived from the NASA Space Radiation Program. (C) 2015 The Committee on Space Research (COSPAR). Published by Elsevier Ltd.

引用

页码：92 / 103

页数：12

共 145 条

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