2-(2-ARYL-2-OXOETHYLIDENE)-1,2,3,4-TETRAHYDROPYRIDINES - NOVEL ISOMERS OF 1,4-DIHYDROPYRIDINE CALCIUM-CHANNEL BLOCKERS

被引:23
作者
TAYLOR, MD [1 ]
BADGER, EW [1 ]
STEFFEN, RP [1 ]
HALEEN, SJ [1 ]
PUGSLEY, TA [1 ]
SHIH, YH [1 ]
WEISHAAR, RE [1 ]
机构
[1] PARKE DAVIS PHARMACEUT RES, DEPT PHARMACOL, ANN ARBOR, MI 48105 USA
关键词
D O I
10.1021/jm00403a030
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
引用
收藏
页码:1659 / 1664
页数:6
相关论文
共 27 条
[1]   DIETHYL 3,6-DIHYDRO-2,4-DIMETHYL-2,6-METHANO-1,3-BENZOTHIAZOCINE-5,11-DICARBOXYLATES AS CALCIUM ENTRY ANTAGONISTS - NEW CONFORMATIONALLY RESTRAINED ANALOGS OF HANTZSCH 1,4-DIHYDROPYRIDINES RELATED TO NITRENDIPINE AS PROBES FOR RECEPTOR-SITE CONFORMATIONE [J].
BALDWIN, JJ ;
CLAREMON, DA ;
LUMMA, PK ;
MCCLURE, DE ;
ROSENTHAL, SA ;
WINQUIST, RJ ;
FAISON, EP ;
KACZOROWSKI, GJ ;
TRUMBLE, MJ ;
SMITH, GM .
JOURNAL OF MEDICINAL CHEMISTRY, 1987, 30 (04) :690-695
[2]   SYNTHESIS OF AN 11-DEOXY-8-AZAPROSTAGLANDIN-E1 INTERMEDIATE [J].
BARCO, A ;
BENETTI, S ;
POLLINI, GP ;
BARALDI, PG ;
SIMONI, D ;
VICENTINI, CB .
JOURNAL OF ORGANIC CHEMISTRY, 1979, 44 (10) :1734-1736
[3]   New therapeutic agents of the quinoline series Part IV Lutidylquinolines [J].
Cook, AH ;
Heilbron, IM ;
Steger, L .
JOURNAL OF THE CHEMICAL SOCIETY, 1943, :413-417
[4]   SYNTHESIS AND CALCIUM-CHANNEL ANTAGONIST ACTIVITY OF DIALKYL 1,4-DIHYDRO-2,6-DIMETHYL-4-(PYRIDINYL)-3,5-PYRIDINEDICARBOXYLATES [J].
DAGNINO, L ;
LIKWONGKEN, MC ;
WOLOWYK, MW ;
WYNN, H ;
TRIGGLE, CR ;
KNAUS, EE .
JOURNAL OF MEDICINAL CHEMISTRY, 1986, 29 (12) :2524-2529
[5]   THE BINDING OF [H-3]-LABELED NITRENDIPINE TO RECEPTORS FOR CALCIUM-CHANNEL ANTAGONISTS IN THE HEART, CEREBRAL-CORTEX, AND ILEUM OF RATS [J].
EHLERT, FJ ;
ROESKE, WR ;
ITOGA, E ;
YAMAMURA, HI .
LIFE SCIENCES, 1982, 30 (25) :2191-2202
[6]  
Eicher T., 1978, LIEBIGS ANN CHEM, P1222
[7]   CRYSTAL-STRUCTURES AND PHARMACOLOGICAL ACTIVITY OF CALCIUM-CHANNEL ANTAGONISTS - 2,6-DIMETHYL-3,5-DICARBOMETHOXY-4-(UNSUBSTITUTED, 3-METHYL-PHENYL, 4-METHYL-PHENYL, 3-NITRO-PHENYL, 4-NITRO-PHENYL, AND 2,4-DINITROPHENYL)-1,4-DIHYDROPYRIDINE [J].
FOSSHEIM, R ;
SVARTENG, K ;
MOSTAD, A ;
ROMMING, C ;
SHEFTER, E ;
TRIGGLE, DJ .
JOURNAL OF MEDICINAL CHEMISTRY, 1982, 25 (02) :126-131
[8]   [H-3]NITRENDIPINE-LABELED CALCIUM CHANNELS DISCRIMINATE INORGANIC CALCIUM AGONISTS AND ANTAGONISTS [J].
GOULD, RJ ;
MURPHY, KMM ;
SNYDER, SH .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1982, 79 (11) :3656-3660
[9]   PD-116,948, A HIGHLY SELECTIVE-A1 ADENOSINE RECEPTOR ANTAGONIST [J].
HALEEN, SJ ;
STEFFEN, RP ;
HAMILTON, HW .
LIFE SCIENCES, 1987, 40 (06) :555-561
[10]  
Hantzsch A., 1882, LIEBIGS ANN CHEM, V215, P1, DOI DOI 10.1002/JLAC.18822150102