REINITIATION OF GROWTH IN SENESCENT MOUSE MAMMARY EPITHELIUM IN RESPONSE TO CHOLERA-TOXIN

被引：24

作者：

DANIEL, CW ^{[1
]}

SILBERSTEIN, GB ^{[1
]}

STRICKLAND, P ^{[1
]}

机构：

[1] UNIV CALIF SANTA CRUZ, THIMANN LABS, DEPT BIOL, SANTA CRUZ, CA 95064 USA

来源：

SCIENCE | 1984年 / 224卷 / 4654期

关键词：

D O I：

10.1126/science.6328652

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Several lines of muose mammary tissue that had been serially transplanted until mitotic senescence was reached were exposed in vivo to plastic implants that slowly released cholera toxin. Gland tissue surrounding the implants displayed new end buds, indicating reinitiation of growth and morphogenesis. The ability of cholera toxin, which elevates intracellular cAMP to temporarily reverse the senescent phenotype suggests that this mitotic dysfunction results not from generalized cellular deterioration but from specific changes in cell regulation.

引用

页码：1245 / 1247

页数：3

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