Lobar variation of carbon tetrachloride hepatotoxicity in the rat

被引:11
作者
Low, D
Thomas, NW
Fry, JR
机构
[1] UNIV NOTTINGHAM,QUEENS MED CTR,SCH MED,DEPT PHYSIOL & PHARMACOL,NOTTINGHAM NG7 2UH,ENGLAND
[2] UNIV NOTTINGHAM,QUEENS MED CTR,SCH MED,DEPT HUMAN MORPHOL,NOTTINGHAM NG7 2UH,ENGLAND
关键词
liver lobes; variation; carbon tetrachloride; hepatotoxicity;
D O I
10.1016/0378-4274(95)03405-6
中图分类号
R99 [毒物学(毒理学)];
学科分类号
100405 ;
摘要
The lobar variation in carbon tetrachloride-induced liver damage in the rat has been assessed by use of a systematic random sampling protocol and quantitative morphometry. A random inter-animal lobar variation in severity of damage was apparent, in contrast with the results obtained previously in which sampling bias, small animal numbers, and lack of fully quantitative measurement were apparent. The route of administration (oral vs. i.p.) did not influence these findings.
引用
收藏
页码:1 / 4
页数:4
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