FACTORS IN THE CEREBROSPINAL-FLUID OF MULTIPLE-SCLEROSIS PATIENTS INTERFERING WITH VOLTAGE-DEPENDENT SODIUM-CHANNELS

被引：26
作者：
BRINKMEIER, H
WOLLINSKY, KH
SEEWALD, MJ
HULSER, PJ
MEHRKENS, HH
KORNHUBER, HH
RUDEL, R
机构：
[1] UNIV ULM,ALLGEMEINE PHYSIOL ABT,ALBERT EINSTEIN ALLEE 11,W-7900 ULM,GERMANY
[2] REHABIL KRANKENHAUS ULM,ANASTHESIOL & INTENS MED ABT,ULM,GERMANY
[3] REHABIL KRANKENHAUS ULM,NEUROL ABT,ULM,GERMANY
来源：
NEUROSCIENCE LETTERS | 1993年 / 156卷 / 1-2期
关键词：
SODIUM CHANNEL; MULTIPLE SCLEROSIS; AUTOIMMUNE DISORDER; HUMAN MYOBALL; WHOLE-CELL RECORDING; CEREBROSPINAL FLUID;
D O I：
10.1016/0304-3940(93)90465-W
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The effect of cerebrospinal fluid (CSF) from patients with multiple sclerosis (MS) on voltage-dependent Na+ channels in human myoballs was studied. The transient Na+ currents, elicited by whole-cell depolarization from -85 to -20 mV, were decreased to 75-25% the control value in the presence of CSF from all 7 MS patients investigated. The effect was complete in about 5 s and was fully reversible on admission of standard external fluid. Such decrease was not or only to a minor extent observed with 10 out of 11 control CSFs from patients without inflammatory neurological disease. The origin of the factors interfering with the Na+ channels is unknown. It is suggested that, in addition to demyelination, impaired Na+ channel function might cause the symptoms in MS.
引用
收藏
页码：172 / 175
页数：4
相关论文
共 18 条
[1]  
BRADLEY J, 1990, CURR OPIN NEUROL NEU, V3, P191
[2]   THE ACUTE PARALYSIS IN GUILLAIN-BARRE-SYNDROME IS RELATED TO A NA+ CHANNEL BLOCKING FACTOR IN THE CEREBROSPINAL-FLUID [J].
BRINKMEIER, H ;
WOLLINSKY, KH ;
HULSER, PJ ;
SEEWALD, MJ ;
MEHRKENS, HH ;
KORNHUBER, HH ;
RUDEL, R .
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 1992, 421 (06) :552-557
[3]   SPECIFIC MODIFICATIONS OF THE MEMBRANE FATTY-ACID COMPOSITION OF HUMAN MYOTUBES AND THEIR EFFECTS ON THE MUSCULAR SODIUM-CHANNELS [J].
BRINKMEIER, H ;
MUTZ, JV ;
SEEWALD, MJ ;
MELZNER, I ;
RUDEL, R .
BIOCHIMICA ET BIOPHYSICA ACTA, 1993, 1145 (01) :8-14
[4]   INTERLEUKIN-2 INHIBITS SODIUM CURRENTS IN HUMAN MUSCLE-CELLS [J].
BRINKMEIER, H ;
KASPAR, A ;
WIETHOLTER, H ;
RUDEL, R .
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 1992, 420 (5-6) :621-623
[5]   KINETICS OF LOCAL-ANESTHETIC INHIBITION OF NEURONAL SODIUM CURRENTS - PH AND HYDROPHOBICITY DEPENDENCE [J].
CHERNOFF, DM ;
STRICHARTZ, GR .
BIOPHYSICAL JOURNAL, 1990, 58 (01) :69-81
[6]  
DAVIS FA, 1981, DEMYELINATING DISEAS, P505
[7]   INACTIVATION OF HUMAN SODIUM-CHANNELS AND THE EFFECT OF TOCAINIDE [J].
FAKLER, B ;
RUPPERSBERG, JP ;
SPITTELMEISTER, W ;
RUDEL, R .
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 1990, 415 (06) :693-700
[8]   INFLAMMATORY MEDIATORS IN DEMYELINATING DISORDERS OF THE CNS AND PNS [J].
HARTUNG, HP ;
JUNG, SF ;
STOLL, G ;
ZIELASEK, J ;
SCHMIDT, B ;
ARCHELOS, JJ ;
TOYKA, KV .
JOURNAL OF NEUROIMMUNOLOGY, 1992, 40 (2-3) :197-210
[9]   IMMUNOHISTOCHEMICAL ANALYSIS OF THE CELLULAR INFILTRATE IN MULTIPLE-SCLEROSIS LESIONS [J].
HAUSER, SL ;
BHAN, AK ;
GILLES, F ;
KEMP, M ;
KERR, C ;
WEINER, HL .
ANNALS OF NEUROLOGY, 1986, 19 (06) :578-587
[10]   CYTOKINE ACCUMULATIONS IN CSF OF MULTIPLE-SCLEROSIS PATIENTS - FREQUENT DETECTION OF INTERLEUKIN-1 AND TUMOR-NECROSIS-FACTOR BUT NOT INTERLEUKIN-6 [J].
HAUSER, SL ;
DOOLITTLE, TH ;
LINCOLN, R ;
BROWN, RH ;
DINARELLO, CA .
NEUROLOGY, 1990, 40 (11) :1735-1739
12