IRRADIATION-RELATED ISCHEMIC-HEART-DISEASE

被引：117
作者：
CORN, BW [1 ]
TROCK, BJ [1 ]
GOODMAN, RL [1 ]
机构：
[1] FOX CHASE CANC INST, DIV CANC CONTROL, PHILADELPHIA, PA 19111 USA
来源：
JOURNAL OF CLINICAL ONCOLOGY | 1990年 / 8卷 / 04期
关键词：
D O I：
10.1200/JCO.1990.8.4.741
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
An expectation for long-term survival has emerged among several groups of cancer patients treated with therapeutic irradiation (eg, Hodgkin's disease, early stage breast cancer). Therefore, the cardiovascular sequelae of thoracic irradiation have recently come under scrutiny. Animal models have demonstrated that cardiac irradiation can directly damage the myocardial microvasculature and can indirectly damage the coronary macrovasculature when coupled with cholesterol feeding. A clear association between thoracic radiotherapy and ischemic heart disease was observed among older clinical studies using radiotherapeutic techniques that are no longer optimal by today's standards. Such a relationship could not be confirmed in modern studies in which treatment factors (such as dose and volume of heart irradiated) were more carefully controlled. © 1990 by American Society of Clinical Oncology.
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页码：741 / 750
页数：10
相关论文
共 65 条
[1]  
AMRONIM GD, 1965, ARCH PATHOL, V75, P219
[2]  
[Anonymous], 1967, INT CLASSIFICATION D
[3]   IONIZING RADIATION ATHEROSCLEROSIS AND LIPID METABOLISM IN PIGEONS [J].
ARTOM, C ;
LOFLAND, HB ;
CLARKSON, TB .
RADIATION RESEARCH, 1965, 26 (02) :165-&
[4]  
BIRAN S, 1969, Clinical Radiology, V20, P433, DOI 10.1016/S0009-9260(69)80100-5
[5]  
BOIVIN JF, 1982, CANCER-AM CANCER SOC, V49, P2470, DOI 10.1002/1097-0142(19820615)49:12<2470::AID-CNCR2820491210>3.0.CO
[6]  
2-Y
[7]   CONFIDENCE-INTERVALS EXTRACT CLINICALLY USEFUL INFORMATION FROM DATA [J].
BRAITMAN, LE .
ANNALS OF INTERNAL MEDICINE, 1988, 108 (02) :296-298
[8]   RADIATION HEART-DISEASE - ANALYSIS OF 16 YOUNG (AGED 15 TO 33 YEARS) NECROPSY PATIENTS WHO RECEIVED OVER 3,500 RADS TO THE HEART [J].
BROSIUS, FC ;
WALLER, BF ;
ROBERTS, WC .
AMERICAN JOURNAL OF MEDICINE, 1981, 70 (03) :519-530
[9]   DETECTION OF RADIATION CARDIOMYOPATHY BY GATED RADIONUCLIDE ANGIOGRAPHY [J].
BURNS, RJ ;
BARSHLOMO, BZ ;
DRUCK, MN ;
HERMAN, JG ;
GILBERT, BW ;
PERRAULT, DJ ;
MCLAUGHLIN, PR .
AMERICAN JOURNAL OF MEDICINE, 1983, 74 (02) :297-302
[10]  
BYHARDT R, 1975, CANCER-AM CANCER SOC, V35, P795, DOI 10.1002/1097-0142(197503)35:3<795::AID-CNCR2820350335>3.0.CO
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