Therapeutic approaches in the management of locally advanced rectal cancer

被引:7
作者
Fung-Kee-Fung, Simon D. [1 ]
机构
[1] Roswell Pk Canc Inst, Dept Radiat Med, Elm & Carlton Str, Buffalo, NY 14263 USA
关键词
Rectal cancer; neoadjuvant therapy; combined modality therapy; radiation therapy;
D O I
10.3978/j.issn.2078-6891.2014.067
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Combined-modality therapy, using radiotherapy and chemotherapy with surgery, has been the traditional therapeutic algorithm for locally advanced rectal cancer. Standard of care in the United States has evolved to include neoadjuvant concurrent chemotherapy and radiotherapy followed by surgical excision and adjuvant chemotherapy. This approach has led to a significant improvement in local recurrences (LR), to the point where distant sites are the more common site of failure. Further improvements in local control have failed to improve overall survival. This article reviews historical trials that shifted the treatment paradigm to the current standard of care, as well as recent research trials, which have sought to incorporate new treatment methodologies, and treatment agents to improve outcomes. Finally this article describes ongoing studies and their potential impact on the future of therapeutic management of locally-advanced rectal cancer.
引用
收藏
页码:353 / 361
页数:9
相关论文
共 54 条
[1]  
ALLEGRA CJ, 2014, J CLIN ONCOL S, V32
[2]   Chemotherapy with preoperative radiotherapy in rectal cancer [J].
Bosset, Jean-Francois ;
Collette, Laurence ;
Calais, Gilles ;
Mineur, Laurent ;
Maingon, Philippe ;
Radosevic-Jelic, Ljiljana ;
Daban, Alain ;
Bardet, Etienne ;
Beny, Alexander ;
Ollier, Jean-Claude .
NEW ENGLAND JOURNAL OF MEDICINE, 2006, 355 (11) :1114-1123
[3]   Fluorouracil-based adjuvant chemotherapy after preoperative chemoradiotherapy in rectal cancer: long-term results of the EORTC 22921 randomised study [J].
Bosset, Jean-Francois ;
Calais, Gilles ;
Mineur, Laurent ;
Maingon, Philippe ;
Stojanovic-Rundic, Suzana ;
Bensadoun, Rene-Jean ;
Bardet, Etienne ;
Beny, Alexander ;
Ollier, Jean-Claude ;
Bolla, Michel ;
Marchal, Dominique ;
Van Laethem, Jean-Luc ;
Klein, Vincent ;
Giralt, Jordi ;
Clavere, Pierre ;
Glanzmann, Christoph ;
Cellier, Patrice ;
Collette, Laurence .
LANCET ONCOLOGY, 2014, 15 (02) :184-190
[4]   Long-term results of a randomized trial comparing preoperative short-course radiotherapy with preoperative conventionally fractionated chemoradiation for rectal cancer [J].
Bujko, K. ;
Nowacki, M. P. ;
Nasierowska-Guttmejer, A. ;
Michalski, W. ;
Bebenek, M. ;
Kryj, M. .
BRITISH JOURNAL OF SURGERY, 2006, 93 (10) :1215-1223
[5]   Sphincter preservation following preoperative radiotherapy for rectal cancer: report of a randomised trial comparing short-term radiotherapy vs. conventionally fractionated radiochemotherapy [J].
Bujko, K ;
Nowacki, MP ;
Nasierowska-Guttmejer, A ;
Michalski, W ;
Bebenek, AB ;
Pudelko, M ;
Kryj, A ;
Oledzki, J ;
Szmeja, J ;
Sluszniak, J ;
Serkies, K ;
Kladny, J ;
Pamucka, A ;
Kukolowicz, P .
RADIOTHERAPY AND ONCOLOGY, 2004, 72 (01) :15-24
[6]  
CASS AW, 1976, CANCER, V37, P2861, DOI 10.1002/1097-0142(197606)37:6<2861::AID-CNCR2820370643>3.0.CO
[7]  
2-3
[8]   Neoadjuvant capecitabine and oxaliplatin before chemoradiotherapy and total mesorectal excision in MRI-defined poor-risk rectal cancer: a phase 2 trial [J].
Chua, Yu Jo ;
Barbachano, Yolanda ;
Cunningham, David ;
Oates, Jacqui R. ;
Brown, Gina ;
Wotherspoon, Andrew ;
Tait, Diana ;
Massey, Alison ;
Tebbutt, Niall C. ;
Chau, Ian .
LANCET ONCOLOGY, 2010, 11 (03) :241-248
[9]   Patients with curative resection of cT3-4 rectal cancer after Preoperative radiotherapy or radiochemotherapy:: Does anybody benefit from adjuvant fluorouracil-based chemotherapy?: A trial of the European organisation for research and treatment of cancer radiation oncology group [J].
Collette, Laurence ;
Bosset, Jean-Francois ;
den Dulk, Marcel ;
Nguyen, France ;
Mineur, Laurent ;
Maingon, Philippe ;
Radosevic-Jelic, Ljiljana ;
Pierart, Marianne ;
Calais, Gilles .
JOURNAL OF CLINICAL ONCOLOGY, 2007, 25 (28) :4379-4386
[10]   PHASE II TRIAL OF NEOADJUVANT BEVACIZUMAB, CAPECITABINE, AND RADIOTHERAPY FOR LOCALLY ADVANCED RECTAL CANCER [J].
Crane, Christopher H. ;
Eng, Cathy ;
Feig, Barry W. ;
Das, Prajnan ;
Skibber, John M. ;
Chang, George J. ;
Wolff, Robert A. ;
Krishnan, Sunil ;
Hamilton, Stanley ;
Janjan, Nora A. ;
Maru, Dipen M. ;
Ellis, Lee M. ;
Rodriguez-Bigas, Miguel A. .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2010, 76 (03) :824-830