BIOTRANSFORMATION OF 1-BENZYL-1,2,3,4-TETRAHYDRO-2-METHYLISOQUINOLINES INTO TETRAHYDROPROTOBERBERINES WITH RAT-LIVER ENZYMES

被引：28

作者：

KAMETANI, T ^{[1
]}

TAKEMURA, M ^{[1
]}

IHARA, M ^{[1
]}

TAKAHASHI, K ^{[1
]}

FUKUMOTO, K ^{[1
]}

机构：

[1] TOHOKU UNIV, INST PHARM, SENDAI, JAPAN

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 1976年 / 98卷 / 07期

关键词：

D O I：

10.1021/ja00423a051

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The biotransformation of reticuline into coreximine, scoulerine and norreticuline with a whole rat or a rat liver preparation in the presence of NADPH was demonstrated by tracer experiments using radioactive (.+-.)-reticuline. Tritium-labeled laudanosine was also incorporated into xylopinine, tetrahydropalmatine, and norlaudanosine with the same rat liver preparation.

引用

页码：1956 / 1959

页数：4

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