A MATHEMATICAL-MODEL OF CYCLE-SPECIFIC CHEMOTHERAPY

被引：105

作者：

PANETTA, JC

ADAM, J

机构：

[1] Department of Mathematics and Statistics, Old Dominion University Norfolk

来源：

MATHEMATICAL AND COMPUTER MODELLING | 1995年 / 22卷 / 02期

关键词：

PERIODIC DIFFERENTIAL EQUATION; CANCER; CHEMOTHERAPY; CELL-CYCLE; QUIESCENCE;

D O I：

10.1016/0895-7177(95)00112-F

中图分类号：

TP39 [计算机的应用];

学科分类号：

081203 ; 0835 ;

摘要：

A mathematical model is used to discuss the effects of cycle-specific chemotherapy. The model includes a constraint equation which describes the effects of the drugs on sensitive normal tissue such as bone marrow. This model investigates both pulsed and piecewise-continuous chemotherapeutic effects and calculates the parameter regions of acceptable dose and period. It also identifies the optimal period needed for maximal tumor reduction. Examples are included concerning the use of growth factors and how they can enhance the cell kill of the chemotherapeutic drugs.

引用

页码：67 / 82

页数：16