Inducers of adipose conversion activate transcription promoted by a peroxisome proliferators response element in 3T3-L1 cells

被引：20

作者：

Brandes, R ^{[1
]}

Arad, R ^{[1
]}

BarTana, J ^{[1
]}

机构：

[1] HEBREW UNIV JERUSALEM,FAC MED,DEPT HUMAN NUTR & METAB,IL-91120 JERUSALEM,ISRAEL

来源：

BIOCHEMICAL PHARMACOLOGY | 1995年 / 50卷 / 11期

关键词：

fatty acids; peroxisome proliferators activated receptors; adipose conversion;

D O I：

10.1016/0006-2952(95)02082-9

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Nonmetabolizable fatty acids are shown here to induce adipose conversion of 3T3-L1 preadipocytes as well as to activate transcription of a reporter plasmid promoted by a peroxisome proliferators response element. This dual activity was also observed using the peroxisome proliferator bezafibrate or the differentiation inducer isobutyl methylxanthine. The data suggest a role for a peroxisome proliferators activated receptor (PPAR) in adipose conversion induced by fatty acids, isobutyl methylxanthine, or xenobiotic amphipathic carboxylates.

引用

页码：1949 / 1951

页数：3

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