SYNTHESIS OF ENANTIOMERICALLY PURE SYN AND ANTI ALPHA-HYDROXY BETA-AMINO ACIDS THROUGH DIASTEREOSELECTIVE HYDROXYLATION OF PERHYDROPYRIMIDIN-4-ONES

被引：14

作者：

CARDILLO, G ^{[1
]}

TOLOMELLI, A ^{[1
]}

TOMASINI, C ^{[1
]}

机构：

[1] UNIV BOLOGNA,CSFM,I-40126 BOLOGNA,ITALY

来源：

TETRAHEDRON | 1995年 / 51卷 / 43期

关键词：

D O I：

10.1016/0040-4020(95)00744-S

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The diastereoselective hydroxylation at C-5 of chiral 6-substituted perhydropyrimidin-4-ones is described. The diastereoselection depends on the base and the hydroxylating agent utilised and on the absolute configuration of the exocyclic phenylethyl moiety. The acid hydrolysis of 5-hydroxy-6-methyl perhydropyrimidin-4 ones furnishes the enantiomerically pure L-isothreonine and D-alloisothreonine.

引用

收藏

页码：11831 / 11840

页数：10

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