Magnetic resonance imaging contrast agents: Overview and perspectives

被引：156

作者：

Yan, Guo-Ping ^{[1
,2
]}

Robinson, Leslie ^{[3
]}

Hogg, Peter ^{[3
]}

机构：

[1] Wuhan Inst Technol, Sch Mat Sci & Engn, 693 Xiongchu Rd, Wuhan 430073, Hubei Province, Peoples R China

[2] Queensland Univ Technol, Sch Phys & Chem Sci, Brisbane, Qld 4001, Australia

[3] Univ Salford, Sch Hlth Care Profess, Manchester M6 6PU, Lancs, England

来源：

RADIOGRAPHY | 2007年 / 13卷

基金：

澳大利亚研究理事会;

关键词：

Magnetic resonance imaging (MRI); Contrast agents; Paramagnetic; Superparamagnetic; Gadolinium(III); Tissue or organ-targeting;

D O I：

10.1016/j.radi.2006.07.005

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Magnetic resonance imaging (MRI) is a non-invasive clinical imaging modality, which has become widely used in the diagnosis and/or staging of human diseases around the world. Some MRI examinations include the use of contrast agents. The categorizations of currently available contrast agents have been described according to their effect on the image, magnetic behavior and biodistribution in the body, respectively. In this field, superparamagnetic iron oxide particles and soluble paramagnetic metal chelates are two main classes of contrast agents for MRI. This review outlines the research and development of MRI contrast agents. In future, the ideal MRI contrast agent will be focused on the neutral tissue-or organ-targeting materials with high relaxivity and specificity, low toxicity and side effects, suitable long intravascular duration and excretion time, high contrast enhancement with low dose in vivo, and with minimal cost. (C) 2006 The College of Radiographers. Published by Elsevier Ltd. All rights reserved.

引用

页码：E5 / E19

页数：15

共 171 条

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