SUGAR MODIFIED OLIGONUCLEOTIDES .2. SOLID-PHASE SYNTHESIS OF NUCLEASE RESISTANT ALPHA-ANOMERIC URIDYLATES AS POTENTIAL ANTISENSE AGENTS

被引：23

作者：

DEBART, F ^{[1
]}

RAYNER, B ^{[1
]}

IMBACH, JL ^{[1
]}

机构：

[1] UNIV MONTPELLIER SCI & TECH LANGUEDOC 2,CNRS,CHIM BIOORGAN LAB,PL EUGENE BATAILLON,F-34095 MONTPELLIER 5,FRANCE

来源：

TETRAHEDRON LETTERS | 1990年 / 31卷 / 25期

关键词：

D O I：

10.1016/S0040-4039(00)94436-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

α-anomeric uridylates, α-rU6 and α-rU12, have been synthesized for the first time. These non natural α-oligoribonucleotides strongly resist to enzymatic degradation and bind to complementary RNA strands. © 1990.

引用

页码：3537 / 3540

页数：4

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