Human Papillomavirus Genotyping and E6/E7 mRNA Expression in GreekWomen with Intraepithelial Neoplasia and Squamous Cell Carcinoma of the Vagina and Vulva

被引：18

作者：

Tsimplaki, Elpida ^{[1
]}

Argyri, Elena ^{[1
]}

Michala, Lina ^{[2
]}

Kouvousi, Maria ^{[1
]}

Apostolaki, Aikaterini ^{[3
]}

GeorgeMagiakos ^{[4
]}

Papassideri, Issidora ^{[5
]}

Panotopoulou, Efstathia ^{[1
]}

机构：

[1] Reg Anticancer Oncol Hosp Athens St Savvas, Dept Virol, G Papanicolaou Res Ctr Oncol & Expt Surg, 171 Alexandras Ave, Athens 11522, Greece

[2] Univ Athens, Dept Obstet & Gynecol 1, Alexandra Hosp, Athens 11528, Greece

[3] Reg Anticanc Oncol Hosp Athens St Savvas, Dept Pathol, Athens 11522, Greece

[4] Reg Anticanc Oncol Hosp Athens St Savvas, Dept Gynecol 1, Athens 11522, Greece

[5] Univ Athens, Dept Cell Biol & Biophys, Fac Biol, Athens 15784, Greece

来源：

JOURNAL OF ONCOLOGY | 2012年 / 2012卷

关键词：

D O I：

10.1155/2012/893275

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A large proportion of vaginal and vulvar squamous cell carcinomas (SCCs) and intraepithelial neoplasias (VAIN and VIN) are associated with HPV infection, mainly type 16. The purpose of this study was to identify HPV genotypes, as well as E6/E7 mRNA expression of high-risk HPVs (16, 18, 31, 33, and 45) in 56 histology samples of VAIN, VIN, vaginal, and vulvar SCCs. HPV was identified in 56% of VAIN and 50% of vaginal SCCs, 71.4% of VIN and 50% of vulvar SCCs. E6/E7 mRNA expression was found in one-third of VAIN and in all vaginal SCCs, 42.9% of VIN and 83.3% of vulvar SCCs. Our data indicated that HPV 16 was the commonest genotype identified in VAIN and VIN and the only genotype found in SCCs of the vagina and vulva. These findings may suggest, in accordance with other studies, that mRNA assay might be useful in triaging lesions with increased risk of progression to cancer.

引用

页数：7

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