CHLORIDE CHANNELS OF INTRACELLULAR ORGANELLES

被引：97
作者：
ALAWQATI, Q
机构：
[1] Q Al-Awqati, College of Physicians and Surgeons, Columbia University, New York, NY 10032
来源：
CURRENT OPINION IN CELL BIOLOGY | 1995年 / 7卷 / 04期
关键词：
D O I：
10.1016/0955-0674(95)80006-9
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Chloride channels are present in a variety of intracellular organelles (Golgi, endosomes, endoplasmic reticulum, and sarcoplasmic reticulum) where they serve largely to shunt the membrane potential created by other ion-translocating processes. Electrophysiological studies have shown that the Cl- channels of the endoplasmic and sarcoplasmic reticula facilitate the efflux of Ca2+. In the Golgi and some endosomes, the open Cl- channels (probably the cystic fibrosis transmembrane conductance regulator) favor accumulation of H+.
引用
收藏
页码：504 / 508
页数：5
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