ELEVATED TUMOR-NECROSIS-FACTOR-ALPHA IN ASSOCIATION WITH SEVERE ANEMIA IN HUMAN-IMMUNODEFICIENCY-VIRUS INFECTION AND MYCOBACTERIUM-AVIUM-INTRACELLULARE INFECTION

被引：16

作者：

ELLAURIE, M ^{[1
]}

RUBINSTEIN, A ^{[1
]}

机构：

[1] ALBERT EINSTEIN COLL MED,DEPT PEDIAT,BRONX,NY 10467

来源：

PEDIATRIC HEMATOLOGY AND ONCOLOGY | 1995年 / 12卷 / 03期

关键词：

AIDS; ANEMIA; HIV; MYCOBACTERIUM AVIUM INTRACELLULARE (MAI); TUMOR NECROSIS FACTOR (TNF);

D O I：

10.3109/08880019509029563

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Mycobacterium avium intracellulare (MAI) infection is a serious opportunistic infection that occurs in children with human immunodeficiency virus (HIV) infection. In MAI the hematologic system is profoundly affected. In the present study the hematologic manifestations of MAI in 37 HIV-infected infants and children were reviewed. Anemia was the predominant feature in all patients, with severe anemia (hemoglobin < 6 g/dL) occurring in 7 of 34 (21%) patients. This was followed by leukopenia (79%), monocytosis (82%), thrombocytopenia (59%), leukoerythroblastic reaction (68%), and neutropenia (41%). Serum tumor necrosis factor (TNF)-alpha was markedly elevated in all patients with MAI with an X +/- SE of 702 +/- 182 pg/mL. There was an association between elevated TNF-alpha and anemia in these patients.

引用

页码：221 / 230

页数：10

共 24 条

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