PROTEOLYSIS - THE PROTEASOME - A PROTEIN-DEGRADING ORGANELLE

被引：135

作者：

RUBIN, DM

FINLEY, D

机构：

[1] Department of Cell Biology, Harvard Medical School, Boston, MA 02115

来源：

CURRENT BIOLOGY | 1995年 / 5卷 / 08期

关键词：

D O I：

10.1016/S0960-9822(95)00172-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The crystal structure of the proteasome suggests that degradation of ubiquitin-protein conjugates is achieved by unfolding the protein substrate and translocating it through a channel into a peptidase-containing chamber.

引用

页码：854 / 858

页数：5