EFFECT OF NIFEDIPINE MONOTHERAPY ON PLATELET-AGGREGATION IN PATIENTS WITH UNTREATED ESSENTIAL-HYPERTENSION

被引：7
作者：
OSMIALOWSKA, Z
NARTOWICZSLONIEWSKA, M
SLOMINSKI, JM
KRUPAWOJCIECHOWSKA, B
机构：
[1] MED ACAD GDANSK,INST INTERNAL MED,DEPT DIAGNOST LAB,PL-80416 GDANSK,POLAND
[2] MED ACAD GDANSK,INST INTERNAL MED,INTERNAL DIS CLIN 2,PL-80416 GDANSK,POLAND
[3] MED ACAD GDANSK,INST PATHOPHYSIOL,DEPT PATHOPHYSIOL,PL-80416 GDANSK,POLAND
来源：
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY | 1990年 / 39卷 / 04期
关键词：
hypertension; lipids; nifedipine; platelet aggregation;
D O I：
10.1007/BF00315419
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The effect of 6 weeks of nifedipine 30-60 mg/d on platelet aggregation and lipid parameters has been studied. A diminution in ADP-, adrenaline- and collagen-induced aggregation was observed. In the case of adrenaline-and collagen-stimulated aggregation the decrease was statistically significant. It was found that platelets which aggregated markedly during the placebo treatment were most strongly inhibited by nifedipine. The changes in lipid parameters were not significantly correlated with changes in aggregation. © 1990 Springer-Verlag.
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页码：403 / 404
页数：2
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