ROLE OF ENDOTHELIN IN THE EXERCISE INTOLERANCE OF CHRONIC HEART-FAILURE

被引：74

作者：

KRUM, H

GOLDSMITH, R

WILSHIRECLEMENT, M

MILLER, M

PACKER, M

机构：

[1] COLUMBIA UNIV,COLL PHYS & SURG,DIV CIRCULATORY PHYSIOL,CTR HEART FAILURE RES,NEW YORK,NY

[2] MT SINAI MED CTR,NEW YORK,NY 10029

来源：

AMERICAN JOURNAL OF CARDIOLOGY | 1995年 / 75卷 / 17期

关键词：

D O I：

10.1016/S0002-9149(99)80783-8

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In conclusion, plasma levels of the endothelialderived vasoconstrictor endothelin-1 (but not those of other neurohormonal vasoconstrictor factors), measured during exercise correlated closely with objective variables of exercise capacity in patients with heart failure. These findings suggest that endothelin-1 may contribute to exercise intolerance in patients with heart failure, perhaps by limiting the ability of the peripheral vasculature to dilate during exercise. © 1995 Excerpta Medica, Inc. All rights reserved.

引用

页码：1282 / 1283

页数：2

共 7 条

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