HUMAN MACROPHAGE METABOLISM OF LOW-DENSITY-LIPOPROTEIN OXIDIZED BY STIMULATED NEUTROPHILS AND FERRITIN

被引：14
作者：
ABDALLA, DSP
COSTAROSA, LFBP
MONTEIRO, HP
CAMPA, A
CURI, R
机构：
[1] UNIV SAO PAULO,INST CIENCIAS BIOMED,BR-05508 SAO PAULO,BRAZIL
[2] FDN HEMOCENTRO SAO PAULO,SAO PAULO,BRAZIL
来源：
ATHEROSCLEROSIS | 1994年 / 107卷 / 02期
基金：
巴西圣保罗研究基金会;
关键词：
OXIDIZED LDL; NEUTROPHILS; FERRITIN; HUMAN MACROPHAGES; FOAM CELLS;
D O I：
10.1016/0021-9150(94)90017-5
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The metabolism of low density lipoprotein (LDL) oxidized with phorbol myristate acetate (PMA) stimulated neutrophils plus ferritin (LDLox) by human monocyte-derived macrophage (HMDM) was studied. Binding of I-125-labeled LDLox to HMDM and further uptake and degradation were higher than for native I-125-labeled LDL. LDLox seems to be taken up by HMDM through the scavenger receptor as indicated by competition studies with unlabeled native and autoxidized LDL. An increased concentration of cellular cholesteryl esters was observed in HMDM exposed to LDLox. Oxidative modification of LDL increased its electrophoretic migration on agarose gel and also the fragmentation of apolipoprotein B. Data suggest that LDLox is incorporated by human macrophages and can potentially induce foam-cell formation.
引用
收藏
页码：157 / 163
页数：7
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