FUNCTIONAL EVIDENCE FOR AN APICAL ANP RECEPTOR IN LLC-PK1 KIDNEY EPITHELIAL-CELLS

被引：0
|
作者：
HASHIMOTO, Y
OZAKI, J
YASUHARA, M
HORI, R
SUGA, S
ITOH, H
NAKAO, K
INUI, K
机构：
[1] KYOTO UNIV HOSP,FAC MED,DEPT PHARM,SAKYO KU,KYOTO 606,JAPAN
[2] KINKI UNIV,INST PHARMACEUT RES & TECHNOL,OSAKA,OSAKA 577,JAPAN
[3] KYOTO UNIV,FAC MED,DEPT MED,DIV 2,SAKYO KU,KYOTO 606,JAPAN
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY-MOLECULAR PHARMACOLOGY SECTION | 1994年 / 268卷 / 03期
关键词：
ANP (ATRIAL NATRIURETIC PEPTIDE); NATRIURETIC PEPTIDE; C-TYPE; GUANYLATE CYCLASE; LLC-PK1; CELL;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The localization of natriuretic peptide receptors was studied in LLC-PK1 cell monolayers grown on a micro-porous membrane filter. The addition of alpha-human atrial natriuretic peptide (alpha-hANP) to the apical side of the cells produced a concentration-dependent increase in cyclic GMP (cGMP) formation, the extent of which was similar to that produced by the addition to the basolateral side. More cGMP was formed with alpha-hANP (1 and 100 nM) than with the C-type natriuretic peptide (100 nM). These findings indicate that the biologically active receptors with high efficacy for alpha-hANP are expressed in both the apical and basolateral membranes in LLC-PK1 cells.
引用
收藏
页码：443 / 445
页数：3
相关论文
共 50 条
  • [31] Decreased secretory transport of a quarternary ammonium, TBuMA, across LLC-PK1 cells by the anionic kidney extract
    Shim, Won-Sik
    Choi, Min-Koo
    Kim, In-Wha
    Kwon, Tae-Sik
    Song, Im-Sook
    Han, Liwei
    Kim, Dae-Duk
    Chung, Suk-Jae
    Shim, Chang-Koo
    ARCHIVES OF PHARMACAL RESEARCH, 2008, 31 (05) : 671 - 677
  • [32] Differential toxic effects of gentamicin on cultured renal epithelial cells (LLC-PK1) on application to the brush border membrane or the basolateral membrane
    Kiyomiya, K
    Matsushita, N
    Matsuo, S
    Kurebe, M
    JOURNAL OF VETERINARY MEDICAL SCIENCE, 2000, 62 (09) : 971 - 975
  • [33] Cadmium-bound metallothionein induces apoptosis in rat kidneys, but not in cultured kidney LLC-PK1 cells
    Ishido, M
    Tohyama, C
    Suzuki, T
    LIFE SCIENCES, 1999, 64 (09) : 797 - 804
  • [34] Effect of cyclosporin A on nitric oxide production in cultured LLC-PK1 cells
    Lima, R
    Serone, AP
    Schor, N
    Higa, EMS
    RENAL FAILURE, 2001, 23 (01) : 43 - 52
  • [35] Preventive Effect of Muscone against Cisplatin Nephrotoxicity in LLC-PK1 Cells
    Phung, Hung Manh
    Lee, Sullim
    Hwang, Ji Hye
    Kang, Ki Sung
    BIOMOLECULES, 2020, 10 (10) : 1 - 11
  • [36] Effects of P-glycoprotein inhibitors on cadmium accumulation in cultured renal epithelial cells, LLC-PK1, and OK
    Endo, T
    Kimura, O
    Sakata, M
    TOXICOLOGY AND APPLIED PHARMACOLOGY, 2002, 185 (03) : 166 - 171
  • [37] Ameliorative effect of adenosine on hypoxia-reoxygenation injury in LLC-PK1, a porcine kidney cell line
    Yonehana, T
    Gemba, M
    JAPANESE JOURNAL OF PHARMACOLOGY, 1999, 80 (02) : 163 - 167
  • [38] Effect of side chains including the N-methyl-tetrazole-thiol group of β-lactam antibiotics on transport in cultured kidney epithelial cells LLC-PK1
    Goto, K
    Oda, M
    Saitoh, H
    Nishida, M
    Takada, M
    BIOLOGICAL & PHARMACEUTICAL BULLETIN, 1998, 21 (10) : 1113 - 1116
  • [39] c-myc is not involved in cadmium-elicited apoptotic pathway in porcine kidney LLC-PK1 cells
    Ishido, M
    Tohyama, C
    Suzuki, T
    LIFE SCIENCES, 1998, 63 (14) : 1195 - 1204
  • [40] Elucidation of protective effects of oxime derivatives against cisplatin-induced cytotoxicity in LLC-PK1 kidney cells
    Lee, Dahae
    Lee, Sang Hyuk
    Lee, Heesu
    Choi, You-Kyung
    Kang, Ki Sung
    Lee, Jae Wook
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2023, 80
12345