MACROPHAGE-COLONY-STIMULATING FACTOR-PRODUCING MALIGNANT HISTIOCYTOSIS

被引：1
|
作者：
OZAKI, S
MATSUSHITA, T
IDE, M
OZAKI, K
SANO, T
KOSAKA, M
SAITO, S
机构：
[1] UNIV TOKUSHIMA,SCH MED,DEPT INTERNAL MED 1,TOKUSHIMA 770,JAPAN
[2] UNIV TOKUSHIMA,SCH MED,DEPT PATHOL 1,TOKUSHIMA 770,JAPAN
来源：
BRITISH JOURNAL OF HAEMATOLOGY | 1995年 / 90卷 / 02期
关键词：
MALIGNANT HISTIOCYTOSIS; MACROPHAGE; M-CSF; NEUTROPHILIA; CYTOKINE;
D O I：
10.1111/j.1365-2141.1995.tb05173.x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
We describe a patient with malignant histiocytosis who had a prominent neutrophilia uncommonly observed in this disease. Serum concentration of macrophage colony-stimulating factor (M-CSF) was markedly elevated, and correlated with clinical symptoms and neutrophil counts during clinical course. Moreover, M-CSF was detected in the cytoplasm of malignant histiocytes of the lymph node and bone marrow by immunochistochemical staining. These results indicate that the neutrophilia observed in this patient was caused by M-CSF produced by the malignant histiocytes.
引用
收藏
页码：453 / 456
页数：4
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