MECHANISM OF SELF-TOLERANCE OF GAMMA-DELTA T-CELLS IN EPITHELIAL TISSUE

被引：54
作者：
BARRETT, TA
DELVY, ML
KENNEDY, DM
LEFRANCOIS, L
MATIS, LA
DENT, AL
HEDRICK, SM
BLUESTONE, JA
机构：
[1] UPJOHN CO,DIV CELL BIOL,KALAMAZOO,MI 49001
[2] US FDA,CTR BIOL EVALUAT & RES,DIV CYTOKINE BIOL,BETHESDA,MD 20892
[3] UNIV CALIF SAN DIEGO,DEPT BIOL,LA JOLLA,CA 92093
[4] UNIV CALIF SAN DIEGO,CTR CANC,LA JOLLA,CA 92093
来源：
JOURNAL OF EXPERIMENTAL MEDICINE | 1992年 / 175卷 / 01期
关键词：
D O I：
10.1084/jem.175.1.65
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The present study examined mechanisms of tolerance for T cell receptor gamma/delta (TCR-gamma/delta) cells. Using a transgenic (Tg) model, we demonstrate that although alloantigen (Ag)-specific TCR-gamma/ delta-cells are deleted in the thymus and spleen of Ag-bearing mice, intraepithelial lymphocytes (IELs) expressing normal levels of the Tg TCR were present. However, Tg+ IELs from Ag-bearing mice were unresponsive to activation. Furthermore, self-reactive Tg+ IELs decreased in number over time. Thus, in epithelial tissue, Tg TCR-gamma/delta-cells are eliminated subsequent to and most likely as a result of the induction of clonal anergy.
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页码：65 / 70
页数：6
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