ATRIOPEPTINS ARE POTENT INHIBITORS OF ACTH-SECRETION BY RAT ANTERIOR-PITUITARY-CELLS INVITRO - INVOLVEMENT OF THE ATRIAL-NATRIURETIC-FACTOR RECEPTOR DOMAIN OF MEMBRANE-BOUND GUANYLYL CYCLASE

被引:69
作者
DAYANITHI, G [1 ]
ANTONI, FA [1 ]
机构
[1] UNIV OXFORD, DEPT HUMAN ANAT, OXFORD OX1 3QX, ENGLAND
基金
英国惠康基金;
关键词
D O I
10.1677/joe.0.1250039
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The current concept of the regulation of adenohypophysial corticotrophin secretion assigns a stimulatory role to neuropeptides of hypothalamic origin and an inhibitory function to adrenocortical glucocoticoid hormones. It has been shown that in isolated perifused rat anterior pituitary cells atriopeptins (1-28) and (5-28), but not (5-25), potently suppress corticotrophin secretion elicited by 41-residue corticotrophin-releasing factor and arginine vasopressin. The action of atriopeptins is associated with a marked increase in the cellular content of cyclic GMP. Moreover, 8-Br-cyclic GMP, a cell membrane permeant analogue of cyclic GMP, also inhibited secretagogue-stimulated corticotrophin release. It is suggested that atriopeptins of hypothalamic and perhaps of cardiac origin may be functionally significant corticotrophin-release inhibiting factors.
引用
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页码:39 / 44
页数:6
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