Expressions of D2-40, CK19, galectin-3, VEGF and EGFR in papillary thyroid carcinoma

被引：18
作者：
Gong, Lei [1 ]
Chen, Ping [1 ]
Liu, Xianjun [1 ]
Han, Ying [1 ]
Zhou, Yanping [1 ]
Zhang, Weidong [1 ]
Li, Hong [1 ]
Li, Chuanjia [1 ]
Xie, Jiang [1 ]
机构：
[1] Cent Hosp Jilin City, Dept Pathol, Jilin 132011, Jilin, Peoples R China
来源：
GLAND SURGERY | 2012年 / 1卷 / 01期
关键词：
Thyroid neoplasms; papillary carcinoma; D2-40; CK19; galectin-3; VEGF; EGFR; immunohistochemis;
D O I：
10.3978/j.issn.2227-684X.2012.03.02
中图分类号：
R61 [外科手术学];
学科分类号：
摘要：
Objective: To investigate the expressions of D2-40, CK19, galectin-3, VEGF, and EGFR in papillary thyroid carcinoma and their clinical significances. Methods: The expressions of D2-40, CK19, galectin-3, VEGF, and EGFR in 38 cases of papillary thyroid carcinoma and 12 cases of thyroid papillary hyperplasia were detected by immunohistochemical staining. Results: The positive expression rates of D2-40, CK19, Galectin-3, VEGF and EGFR in patients with papillary thyroid carcinoma were all significantly higher than those in patients with thyroid papillary hyperplasia (all P< 0.05). The expressions of D2-40, VEGF, and EGFR in papillary thyroid carcinoma with lymph node metastasis were significantly higher than those without lymph node metastasis (P< 0.05). The expressions of GK19 and galectin-3 showed no significant differences between the papillary thyroid carcinomas with and without lymph node metastasis (P> 0.05). Conclusions: The detection of D2-40, CK19, galectin-3, VEGF, and EGFR is helpful for the diagnosis and differential diagnosis of papillary thyroid carcinoma and thyroid papillary hyperplasia.
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收藏
页码：25 / 32
页数：8
相关论文
共 34 条
  • [1] Differential expression of cytokeratins in follicular variant of papillary carcinoma: An immunohistochemical study and its diagnostic utility
    Baloch, ZW
    Abraham, S
    Roberts, S
    LiVolsi, VA
    [J]. HUMAN PATHOLOGY, 1999, 30 (10) : 1166 - 1171
  • [2] Universal Markers of Thyroid Malignancies: Galectin-3, HBME-1, and Cytokeratin-19
    Barut, Figen
    Kandemir, Nilufer Onak
    Bektas, Sibel
    Bahadir, Burak
    Keser, Sevinc
    Ozdamar, Sukru Oguz
    [J]. ENDOCRINE PATHOLOGY, 2010, 21 (02) : 80 - 89
  • [3] Cytokeratin 19 and galectin-3 immunohistochemistry in the differential diagnosis of solitary thyroid nodules
    Beesley, MF
    McLaren, KM
    [J]. HISTOPATHOLOGY, 2002, 41 (03) : 236 - 243
  • [4] Cytokeratin subtypes in thyroid tumours: Immunohistochemical study with emphasis on the follicular variant of papillary carcinoma
    Cameron, BR
    Berean, KW
    [J]. JOURNAL OF OTOLARYNGOLOGY, 2003, 32 (05) : 319 - 322
  • [5] Distinction between papillary thyroid hyperplasia and papillary thyroid carcinoma by immunohistochemical staining for cytokeratin 19, galectin-3, and HBME-1
    Casey, MB
    Lohse, CM
    Lloyd, RV
    [J]. ENDOCRINE PATHOLOGY, 2003, 14 (01) : 55 - 60
  • [6] Chen Y, 2010, CHINESE J CLIN EXPT, V26, P1061
  • [7] [陈云新 Chen Yunxin], 2010, [临床与实验病理学杂志, Chinese Journal of Clinical and Experimental Pathology], V26, P425
  • [8] Immunohistochemical diagnosis of papillary thyroid carcinoma
    Cheung, CC
    Ezzat, S
    Freeman, JL
    Rosen, IB
    Asa, SL
    [J]. MODERN PATHOLOGY, 2001, 14 (04) : 338 - 342
  • [9] Diagnostic Utility of Galectin-3 in Thyroid Cancer
    Chiu, Connie G.
    Strugnell, Scott S.
    Griffith, Obi L.
    Jones, Steven J. M.
    Gown, Allen M.
    Walker, Blair
    Nabi, Ivan R.
    Wiseman, Sam M.
    [J]. AMERICAN JOURNAL OF PATHOLOGY, 2010, 176 (05) : 2067 - 2081
  • [10] Cvejic D, 2003, Acta Chir Iugosl, V50, P67
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