ASSOCIATION OF HELICOBACTER-PYLORI AND GASTRIC AUTOIMMUNITY - A POPULATION-BASED STUDY

被引：0
作者：
UIBO, R
VOROBJOVA, T
METSKULA, K
KISAND, K
WADSTROM, T
KIVIK, T
机构：
[1] LUND UNIV,DEPT MED MICROBIOL,S-22362 LUND,SWEDEN
[2] KARKSI NUIA OUT PATIENTS DEPT,KARKSI NUIA 3644,ESTONIA
来源：
FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY | 1995年 / 11卷 / 01期
关键词：
HELICOBACTER PYLORI; IGG ANTIBODY; PARIETAL CELL ANTIBODY; GASTRIC AUTOIMMUNITY; CHRONIC GASTRITIS; AMINO ACID SEQUENCE;
D O I：
10.1016/0928-8244(95)00005-R
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Based on clinical studies, a negative association between Helicobacter pylori and autoimmune corpus gastritis is described. In the present investigation of an unselected population of 1461 adults we can state, however, that there exists a relationship between H. pylori infection and the development of gastric corpus autoimmunity. As confirmation for the gastric autoantibody development through molecular mimicry, a high homology (72% in 25 amino acid overlap) between the beta subunit of H. pylori urease and that of H + K + ATPase, the gastric parietal cell autoantigen, was revealed.
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页码：65 / 68
页数：4
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