Photodynamic therapy of small adenocarcinomas with methylene blue

被引:0
作者
Orth, K [1 ]
Ruck, A [1 ]
Beck, G [1 ]
Stanescu, A [1 ]
Beger, HG [1 ]
机构
[1] INST LASERTECHNOL MED,ULM,GERMANY
来源
CHIRURG | 1995年 / 66卷 / 12期
关键词
photodynamic therapy; methylene blue; oesophagus carcinoma;
D O I
暂无
中图分类号
R61 [外科手术学];
学科分类号
摘要
Photodynamic therapy (PDT) is a new method in the treatment of small/early malignancies. It is based on the interaction of a photosensitiser, light and cellular oxygen. A new therapeutic concept with locally applied 1 % of methylene blue into the tumour and subsequent radiation (argon laser pumped dye laser, 665 nm, 100 mW/cm(2), 100 J/cm(2)) was first tested in xenotransplanted carcinomas and then clinically applied. The animal experiments showed a tumour volume reduction of 1:12, as compared to a control group, two weeks after the first PDT-application. After the second PDT-treatment 6 out of 10 tumours were destroyed. Four carcinomas showed inhibited growth after the treatment. The method was clinically applied in 3 patients with local tumour recurrence in the area of the anastomosis after oesophagus resection. 72 hours after PDT-treatment 4-5 mm tumour necrosis could be proven experimentally. PDT was repeated at the same site within 2 weeks. There were no experimental or clinical complications during or after PDT. The treated tumour areas showed no local tumour growth within 6 months after PDT-treatment.
引用
收藏
页码:1254 / 1257
页数:4
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