PREFERRED USAGE OF SPECIFIC IMMUNOGLOBULIN GENE SEGMENTS IN CHRONIC LYMPHOCYTIC-LEUKEMIA CELLS OF 3 HLA-IDENTICAL SISTERS

被引：11

作者：

HAKIM, I

AMARIGLIO, N

BROKSIMONI, F

BERKOWITZ, M

ROSNER, E

KNELLER, A

HULU, N

RAMOT, B

BENBASSAT, I

SILVERMAN, GJ

RECHAVI, G

机构：

[1] TEL AVIV UNIV,CHAIM SHEBA MED CTR,SACKLER SCH MED,INST HAEMATOL,IL-56261 TEL HASHOMER,ISRAEL

[2] UNIV CALIF SAN DIEGO,SAN DIEGO,CA 92103

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 1995年 / 91卷 / 04期

关键词：

IMMUNOGLOBULIN GENE SEGMENTS; CLL; HLA ANTIGEN;

D O I：

10.1111/j.1365-2141.1995.tb05409.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We report three family members, including a set of identical twins, who developed CD5 positive B-CLL. The patients are female Ashkenazi Jews sharing an identical HLA mal studies suggest a process of clonal evolution in one of the phenotype. Two of the HLA loci (B35 and Cw4) were twins. common with those already described as being shared by Ashkenazi Jews with an increased incidence of CLL, The rearranged immunoglobulin genes of the malignant cells of all three patients were found to express genetically related V-H regions belonging to the V-H(3) subgroup, and chromosomal studies suggest a process of clonal evolution in one of the twins.

引用

页码：915 / 917

页数：3