ADAPTIVE CELLULAR INTERACTIONS IN THE IMMUNE-SYSTEM - THE TUNABLE ACTIVATION THRESHOLD AND THE SIGNIFICANCE OF SUBTHRESHOLD RESPONSES

被引：199

作者：

GROSSMAN, Z ^{[1
]}

PAUL, WE ^{[1
]}

机构：

[1] NIAID, IMMUNOL LAB, BETHESDA, MD 20892 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1992年 / 89卷 / 21期

关键词：

CONTEXT DISCRIMINATION; AUTOREACTIVITY; ANERGY; MEMORY UNITS;

D O I：

10.1073/pnas.89.21.10365

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A major challenge for immunologists is to explain how the immune system adjusts its responses to the microenvironmental context in which antigens are recognized. We propose that lymphocytes achieve this by tuning and updating their responsiveness to recurrent signals. In particular, cellular anergy in vivo is a dynamic state in which the threshold for a stereotypic mode of activation has been elevated. Anergy is associated with other forms of cellular activity, not paralysis. Cells engaged in such subthreshold interactions mediate functions such as maintenance of immunological memory and control of infections. In such interactions, patterns of signals are recognized and classified and evoke selective responses. The robust mechanism proposed for segregation of suprathreshold and subthreshold immune responses allows lymphocytes to use recognition of self-antigens in executing physiological functions. Autoreactivity is allowed where it is dissociated from uncontrolled aggression.

引用

页码：10365 / 10369

页数：5

共 30 条

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