THE SYNTHESIS OF METALLOCENE-LABELED DRUGS FOR BIOLOGICAL ASSAYS

被引：35
作者：
LAVASTRE, I
BESANCON, J
BROSSIER, P
MOISE, C
机构：
[1] Laboratoire de Synthèse Et D'electrosynthèse Organomètallique
[2] Unité D'immunoanalyse, Faculté de Pharmacie, Université de Bourgogne, Dijon, 21000
来源：
APPLIED ORGANOMETALLIC CHEMISTRY | 1990年 / 4卷 / 01期
关键词：
benchrotrene; cymantrene; drugs; immunoassay; metallocenic labels; metallohaptens;
D O I：
10.1002/aoc.590040104
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Several drugs (amphetamine, desipramine, nortriptyline, phenobarbital) have been labelled with metallocenic fragments in order to develop a new immunoassay method. The metallocenic fragments are cymantrenic or benchrotrenic derivatives: the linkage between the organic and organometallic moieties has been achieved by reactions between amino and acidic functional groups. All the products (metallohaptens), purified by different chromatography techniques, have been fully characterized by IR and 1H NMR spectroscopy and their mass spectra. Copyright © 1990 John Wiley & Sons Ltd.
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页码：9 / 17
页数：9
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